Already taking a gamble settling in the uncharted west, the peaceful settlers of a town destined for railroad greatness suddenly find themselves being ruthlessly gunned down. With no law and order to be found, justice falls onto the shoulders of an elderly rancher and an accomplished, but retired, gunslinger.

三个大学教授比尔墨瑞、丹艾克洛德、哈洛雷米斯专门研究鬼怪灵异之事，他们决定离开校园，自组一个“捉鬼大队”，以最新科学仪器对付在纽约市出没的猛鬼。他们的捉鬼行动相当成功，数以打计的大鬼小鬼再也无容身之地，但是，政府单位却将他们视为江湖骗术。直到有一天，一群恶鬼包围了纽约市，并附身在美女雪歌妮薇佛（“异形”系列电影）身上，准备在纽约市大举肆虐。此时，无计可施的政府只好召来了捉鬼大队，且看这群“魔鬼克星”是如何让鬼魂无所遁形呢？